Arteriosclerosis, the hardening and narrowing of the arteries, causes a reduction in blood flow throughout the body and can lead to impotence. It is associated with age and accounts for 50% to 60% of Impotence in men over 60.

Risk factors for arteriosclerosis include:

  • Diabetes mellitus
  • High blood pressure
  • High cholesterol

Smoking, which can lead to any of the above risk factors, is perhaps the most significant risk factor for Impotence related to arteriosclerosis.